Grier’s television credits are abundant. Grier is well known as being a principle cast member of the acclaimed television series “In Living Color,” where he helped to create some of that show’s most memorable characters, and also as a co-star on Bonnie Hunt’s hit ABC comedy “Life With Bonnie.” He also starred on the hit NBC show “DAG” where he played the title character, as well Keeping his close comedic relationship with the Wayans’ brothers, he co-starred with Damon Wayans in “Damon.” He also starred in the television miniseries “The 60s,” and “King of Texas” for cable television.

In addition Grier has gained recognition for his numerous feature film roles, including “Baadasssss!” for director Mario Van Peebles, “The Woodsman” opposite Kevin Bacon and Mos Def, “15 Minutes,” “Boomerang,” “Bewitched,” “Jumanji” and Robert Altman’s “Streamers,” for which he won a Golden Lion Award for Best Actor at the Venice Film Festival. David also co-wrote, produced and appeared in the independent film “Poker House,” Lori Petty’s directorial debut.

David recently appreared on the hit tv show Dancing With the Stars in which he danced his heart out for four episodes and then had a very public meltdown when he was eliminated that went viral on the internet. Grier also appeared in the Wayans Family's hit 2009 movie, 'Dance Flick' in which The New York Times gushed "Mr. Grier ultimately steals the movie with a tour-de-force". He is currently working on a stand-up comedy tour that may culminate in a special on Comedy Central about the experiences written about in Barack Like Me!!!