The business of Death is never done. Asato Tsuzuki works as a Shinigami, or "Guardian o Death," in the Ministry of Hades. It's his duty to make sure that the souls of the dead reach the afterlife, but contrary ghosts and humanity's evils keep getting in the way of a job well done. With all these problem assignments, will he ever get a bonus...or will he be stuck paying back damages for all eternity?

Tsuzuki and Hisoka are still caught up in the horror at the university as the evil Dr. Muraki's diabolical cloning experiments continue. Muraki has joined forces with a modern-day Frankenstein in order to resurrect an old enemy and exact a vicious revenge. When Tsuzuki tries to interfere, Muraki takes his mind and body captive. Can Hisoka rescue him from the doctor's clutches before Tsuzuki's final act of desperation destroys them all?