High school students heroic act turns into epic human vs. monster sword fight!

Buso Renkin is the story of teenager Kazuki Muto, who dies trying to save a girl who was being attacked by an eerie monster. The next morning, however, Kazuki is left wondering whether it was all a dream. Lo and behold, the girl, the monster, and his death are all real! The girl, Tokiko Tsumura, was actually trying to slay the homunculus (a beast that can take the form of humans, and whose main source of food is people), but Kazuki got in her way. To revive Kazuki, Tokiko replaces his heart with a "kakugane," an alchemic device that allows him to summon a lance with which to fight the monsters. It turns out that Tokiko is a member of the Alchemist Warriors, an organization sworn to protect the world from the diabolical creatures. Soon, Kazuki joins Tokiko in her quest to terminate the sinister being that creates and controls the homunculus.

Kazuki inadvertently reveals his identity as an Alchemist Warrior to the Hayasaka twins, members of the L.X.E. (League of Extraordinary Elects), when he activates his Buso Renkin in front of them. After Tokiko and Kazuki take on the twins in a late-night battle, they learn the location of the L.X.E. headquarters, and head there along with Captain Bravo. Intending to put an end to Dr. Butterfly's organization, they discover that yet another evil plan has been set in motion...